The Combined Effects of Ionizing Radiation and High Temperature on the Longevity of the Sprague-Dawley Rat

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Abstract
Male Sprague-Dawley rats, individually caged, were exposed to low-level irradiation with chronic dosages from a Co60 source for 16 hours a day. Animals were selected by weight and growth rate and divided into 8 groups of 22 rats. Four groups were kept at 28[degree] [plus or minus] 1[degree]C and exposed to 0.29, 0.64, 2.60, and 4.18 r/day during the irradiation period, which lasted from 4 months of age to 16 months of age. The other groups were kept at 35[degree] [plus or minus] 1[degree]C during the period of irradiation, and exposed to 0.28, 0.60, 2.57, and 3.96 r/day. At 35[degree]C the ET50 for 0.29 r/day was 310; for 0.64 r/day it was 490; for 2.60 r/day it was 540; and for 4.18 r/day it was 510. At 28[degree]C the ET50 for 0.28 r/day was 493; for 0.60 r/day it was 510; for 2.57 r/day it was 650; and for 3.96 r/day it was 590. With the exception of the relation between 0.60 and 0.28 r/day, the data are statistically significant at the 5% level. From a previous experiment at 26[degree]C the ET50 for 0 r/day was 445, and for 0.8 r/day it was 585. It is suggested that the effects of ionizing irradiation interact with the effects of environment in influencing longevity.

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