Apolipoprotein E genotyping in Turkish myocardial infarction survivors and healthy controls
- 1 January 1995
- journal article
- research article
- Published by Springer Nature in Journal of Biomedical Science
- Vol. 2 (1) , 46-49
- https://doi.org/10.1007/bf02257924
Abstract
The apolipoprotein (Apo) E gene is known to be polymorphic. Three common alleles determine six phenotypes which can easily be detected by restriction fragment length polymorphism. We performed apo E genotyping in myocardial infarction survivors and healthy controls for the first time in the Turkish population. DNA was amplified by polymerase chain reaction (PCR) and the PCR product was digested with restriction enzymesHhaI to detect apo E2, E3, E4 and withTaqI to detect apo E1. Relative allele frequency for the patient group was found to be 0.91 for E3, 0.07 for E2, 0.02 for E4 and for the control group 0.875 for E3, 0.067 for E2, 0.058 for E4.Keywords
This publication has 14 references indexed in Scilit:
- Apolipoprotein E1 Lys-146 → Glu with type III hyperlipoproteinemiaBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1992
- Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and & epsilon;1/lsquo;null genotype‡European Journal of Clinical Investigation, 1992
- The role of apolipoprotein E genetic variants in lipoprotein disordersJournal of Internal Medicine, 1992
- Analysis of genetically determined structural polymorphisms in apolipoproteins E, B and (a)Current Opinion in Lipidology, 1991
- Apolipoprotein ECurrent Opinion in Lipidology, 1990
- Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell BiologyScience, 1988
- Reciprocal effects of apolipoprotein E alleles (ε2 AND ε4) on plasma lipid levels in normolipidemic subjectsClinical Genetics, 1986
- Polymorphism at the Apoprotein‐E locus in relation to risk of coronary diseaseClinical Genetics, 1984
- Apolipoprotein E polymorphism and coronary artery disease.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1983
- Declining mortality in coronary heart disease.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1981