Pharmacokinetics of furosemide after three different single oral doses

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Abstract
Furosemide solution was orally administered to 21 healthy adult males to determine dose proportionality over the dose range used and the reproducibility of disposition following a repeated dose. Furosemide solution was given in doses of 20, 40, and 80mg, with the 40 mg dose repeated once. Blood was collected for 12 hours post‐dose and urine for 24 hours. The maximum plasma concentrations resulting from 20, 40, and 80mg doses were significantly different (p < 0.05). Dose normalized maximum concentrations for the 20 and 80 mg doses were significantly different (p < 0.05). Mean time to Cpmax was 50 minutes, with no differences observed among doses. Plasma AUCs were significantly different (p < 0.05) for 20, 40, and 80mg. Dose normalized AUCs were not significantly different. Mean amounts of furosemide in urine (Xu) were 9.62, 16.7, and 32.0 mg for the 20, 40, and 80 mg doses, respectively. These amounts were significantly different (p max, AUC and Xu on dose were significant. There were no significant differences in Cpmax, tmax, AUC or Xu for 40 mg given on two separate days. Renal clearance of furosemide was statistically different for 40mg given on two separate days, but the difference was not clinically significant. The pharmacokinetics of furosemide are linear over the dosage range studied. Furosemide 40 mg given on two separate days results in similar disposition parameters.

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