A Double-Masked, Randomized, 1-Year Study Comparing the Corneal Effects of Dorzolamide, Timolol, and Betaxolol
Open Access
- 1 August 1998
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 116 (8) , 1003-1010
- https://doi.org/10.1001/archopht.116.8.1003
Abstract
DORZOLAMIDE hydrochloride is the first commercially available topical carbonic anhydrase inhibitor and has been in widespread clinical use for the treatment of elevated intraocular pressure (IOP) since May 1995. Dorzolamide is a potent inhibitor of carbonic anhydrase isoenzyme II (CA-II),1 which is found primarily in red blood cells but also in other tissues, including the ciliary processes of the eye.2 Inhibition of CA-II in the ciliary processes results in decreased aqueous humor secretion with subsequent reduction in IOP.Keywords
This publication has 18 references indexed in Scilit:
- Preclinical Ocular Irritation Findings with Dorzolamide HydrochlorideJournal of Toxicology- Cutaneous and Ocular Toxicology, 1997
- Two pathways for electrogenic bicarbonate ion movement across the rabbit corneal endotheliumBiochimica et Biophysica Acta (BBA) - Biomembranes, 1996
- Review The Preclinical Pharmacology of Dorzolamide Hydrochloride, a Topical Carbonic Anhydrase InhibitorJournal of Ocular Pharmacology and Therapeutics, 1996
- A Double-Masked, Randomized 1-Year Study Comparing Dorzolamide (Trusopt), Timolol, and BetaxololArchives of Ophthalmology (1950), 1995
- Four-Week Safety and Efficacy Study of Dorzolamide, a Novel, Active Topical Carbonic Anhydrase InhibitorArchives of Ophthalmology (1950), 1993
- Effects of ambient bicarbonate, phosphate and carbonic anhydrase inhibitors on fluid transport across rabbit corneal endotheliumExperimental Eye Research, 1990
- The mechanism of fluid and electrolyte transport across corneal endothelium: Critical revision and update of a modelCurrent Eye Research, 1985
- Analysis of presteady-state Na+ fluxes across the rabbit corneal endotheliumThe Journal of Membrane Biology, 1982
- Electrical properties of rabbit corneal endothelium as determined from impedance measurementsBiophysical Journal, 1981
- The bicarbonate ion pump in the endothelium which regulates the hydration of rabbit cornea.The Journal of Physiology, 1976