Separation of a New Antidiabetic Agent, N-(Trans-4-Isopropylcyclohexylcarbonyl)-D-Phenylalanine, and its Isomers by Chiral High-Performance Liquid Chromatography
- 28 February 1989
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 12 (3) , 457-464
- https://doi.org/10.1080/01483918908051747
Abstract
N-(trans-4-Isopropylcyclohexylcarbonyl)-D-phenylalanine (A4166) is a new oral antidiabetic agent. In order to determine the purity of chemical samples of A4166, a high-performance liquid chromatographic method for the separation of A4166 and synthetic by-products (an L-enantiomer and a cis-iosmer of A4166) has been developed. A chiral stationary phase column packed with 5 μm N-(tert-butylaminocarbonyl)-L-valylaminopropyl silica gel was used for the direct separation of A4166 and its isomers after derivatization with a non-chiral reagent.This publication has 2 references indexed in Scilit:
- A Convenient Preparation oft-Butyl EstersSynthesis, 1983
- Amino Acid N-Dimethylaminomethylene Alkyl Esters. New Derivatives for GC and GC-MS StudiesAnalytical Letters, 1972