EXPERIMENTAL PROTEIN-LOSING GASTROENTEROPATHY - ROLE OF TISSUE PLASMINOGEN ACTIVATOR

  • 1 January 1976
    • journal article
    • research article
    • Vol. 71  (4) , 631-634
Abstract
The tissue fibrinolytic activity of intestinal mucosa was studied in rats with protein-losing gastroenteropathies experimentally produced by X-irradiation, 5-fluorouracil treatment, or ligation of the thoracic duct. The first two models showed an increase of fibrinolytic activity and of 131I-polyvinylpyrrolidone excretion, and the third showed normal fibrinolysis. 131I-polyvinylpyrrolidone excretion in the 1st 2 groups was markedly reduced by injections of trans-4-aminomethyl cyclohexane carboxylic acid, a potent antiplasmin agent. Tissue fibrinolysis in the digestive mucosa may play an important role in the pathogenesis of protein-losing gastroenteropathy associated with diseases of the mucosa.

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