The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes
- 1 November 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 6 (11) , 799-812
- https://doi.org/10.1038/nri1944
Abstract
The recognition of antigen by B- or T-cell receptors initiates an intracellular signalling cascade that results in the nuclear translocation and activation of the transcription factor nuclear factor-κB (NF-κB). NF-κB is an important regulator of lymphocyte development and function, and its dysregulation is associated with many immune disorders. Defining the mechanisms that transmit signals from the antigen receptor to NF-κB is therefore an important goal for immunologists. In this Review, we merge information gleaned from research of the innate immune system with what we know about antigen-receptor signals in the adaptive immune system, to propose a cohesive model of how antigen receptors activate NF-κB.Keywords
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