The Treatment of Mental Defectives with Thiamine

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Abstract
Thiamine or aneurine has for many years been known as the anti-neuritic vitamin, although action of this substance in organic nervous trouble is not established. Less well-known is its action on the higher cerebral processes, but results of investigations appear to show that it has a definite effect on these. M. V. Dias (1947) found that the application of thiamine hydrochloride solution to the motor cortex of unanaesthetized dogs produced clonic contractions of the appropriate muscles, and Harrell (1946) reports striking psychological results on normal children.