Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin
- 30 June 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 28 (7) , 914-921
- https://doi.org/10.1021/jm00145a012
Abstract
Total syntheses from pyridine precursors of 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin are described. These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.This publication has 1 reference indexed in Scilit:
- Folic acid analogs. III. N‐(2‐[2‐(2,4‐diarnino‐6‐quinazolinyl)ethyl]benzoyl)‐l‐glutamic acidJournal of Heterocyclic Chemistry, 1979