Treatment planning for photodynamic therapy: semi-empirical model and clinical trials on head and neck carcinoma

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Abstract
An optical dosimetry model for photodynamic therapy (PDT) is based on the assumption that the tumor-localized photosensitizer must absorb an energy density threshold for tumor necrosis. The relationship between delivered dose and absorbed energy was calculated for idealized geometries with the photon diffusion equation and calibrated by scaling to PDT results for superficial tumors. The predictions of the model are compared with clinical trials on head and neck malignancies.

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