Short Communication: Metabolism of the bay-region trans-1–2-dihydrodiol of benz(a)anthracene in rat liver microsomes occurs primarily at the 3, 4-double bond

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Abstract
The bay-region hydroxyl groups of benz[a]anth-racene (±)trans-l, 2-dihydrodiol are known to be exclusively in quasi-axial conformations. This dihydro-diol was stereoselectively metabolized in rat liver microsomes to form two optically active 1, 2, 3, 4-tetrahydrotetrols as the predominant products. Thus, the bay-region axial hydroxyl groups of benz[a]-anthracene trans-l, 2-dihydrodiol do not direct metabolism away from the vicinal 3, 4-double bond.