Stimulation-produced analgesia (SPA) from brain-stem and diencephalic sites in the rat: Relationships between analgesia, aversion, seizures and catalepsy

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Abstract
Sion, generalized seizures and catalepsy. Ventrobasal nucleus of thalamus (VB) stimulation did not elicit analgesia or aversion but did induce behavior characteristic of limbic seizures. A sub-anesthetic dose of sodium pentobarbital (20 mg/kg) suppressed IC stimulation-produced generalized seizures and catalepsy, and attenuated, but did not eliminate, tail flick test analgesia. These data suggest that SPA from IC sites in the rat is partially confounded with reduced responsivity. The hypothesis that SPA associated with aversion may represent a form of stress-induced analgesia is discussed. ∗Correspondence to: Dr. M.J. Morgan, Department of Psychology, McGill University, 1205 Dr. Penfield Avenue, Montreal, Que. H3A 1B1, Canada. (Received 1 July 1987; revised 5 October 1987; accepted 9 November 1987.) © Lippincott-Raven Publishers....