Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases
- 1 January 1984
- Vol. 54 (4) , 635-637
- https://doi.org/10.1002/1097-0142(1984)54:4<635::aid-cncr2820540408>3.0.co;2-m
Abstract
PGE2 overproduction by a nephroblastoma associated with hypercalcemia was clearly demonstrated in a 2-month-old girl. Compared with normal tissue, tumor showed greater phospholipase A2 and PGE2 synthetase activities but metabolized PGE2 at a faster rate. Of the enzymes involved in PGE2 synthesis, those which transform arachidonic acid into PGE2 seem to be more active.This publication has 11 references indexed in Scilit:
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