The Diagnosis of Multiple Sclerosis

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Abstract
Multiple sclerosis (MS) has no single clinical or laboratory feature that is specific and establishes the diagnosis. In recent years, many ancillary investigations, such as oligoclonal proteins, evoked potentials, and computed tomographic scans, have become available to aid the clinician. These investigations are summarized, and an algorithm describing an approach to the diagnosis of MS is given. The importance of careful clinical observation overshadows even these newer tests. (JAMA1982;247:498-503)