Bactericidal Action of Modulated Ultraviolet Light on Six Groups of Salmonella

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Abstract
Previous studies on the bactericidal effects of ultraviolet (UV) lamps have focused on the effects of specific wavelengths and the time and intensity of exposure. Virtually all of these studies have used continuous wave UV. Exposure to UV can induce abnormal ion flow or increased membrane permeability, or it can depolarize the membrane, induce DNA, RNA, and protein alterations, and inhibit oxidative phosphorylation. Any periodic alteration in the modulation of the intensity alters the biological effectiveness. If the waveform and pulse repetition rate are chosen carefully, the bactericidal effects of the UV light may be greatly enhanced.We tested a prototype UV-C lamp modulated by a series of complex waveforms designed to enhance bactericidal activity. These experiments evaluated the effectiveness of the modulated WC in a series of in vitro experiments on six serogroups of Salmonella.