Catalytic Multistep Reactions via Palladacycles

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Abstract
This account reports new methodologies to achieve multistep reactions under the catalytic action of palladium complexes. The metal control enables molecular pools consisting of several components to react in a definite order to form products with high chemo-, regio- and stereoselectivity. Key intermediates are palladacycles, which are formed and dismantled in the course of the reaction sequence. 1 Introduction 2 The Background: Arylnorbornylpalladium Complexes in Stoichiometric and Catalytic Reactions 3 Palladium(II) and (IV) Metallacyles 4 Aromatic Alkylation Followed by Norbornene Deinsertion 4.1 Aromatic Alkylation Coupled with the Heck Reaction 4.2 Aromatic Alkylation Coupled with the Suzuki reaction 4.3 Aromatic Alkylation Coupled with Hydrogen Transfer 4.4 Aromatic Alkylation Coupled with a Cassar-Sonogashira-Type Reaction 4.5 Ring Formation Instead of Norbornene Deinsertion 5 Aromatic Arylation 5.1 Aromatic Arylation with Norbornene Incorporation 5.2 Aromatic Arylation Followed by Norbornene Deinsertion: The ortho Effect 5.2.1 Aromatic Arylation Followed by Intramolecular Annulation without Norbornene Deinsertion 5.2.2 Aromatic Arylation Followed by Norbornene Deinsertion and Annulation with Alkynes 5.2.3 Aromatic Arylation Followed by Norbornene Deinsertion and the Suzuki Reaction 5.2.4 Aromatic Arylation Followed by Norbornene Deinsertion and the Heck Reaction 6 Conclusions and Prospects

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