Effect of a cholesterol-rich diet on cholesterol content and phagocytic activity of rat macrophages
- 1 February 1976
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 6 (1-3) , 135-142
- https://doi.org/10.1007/bf01972197
Abstract
Treatment for 11–13 weeks with a cholesterol-rich diet induced increases in free and esterified serum cholesterol. There was also an increase in free cholesterol of peritoneal macrophages. A 2.2 times rise in the cholesterol to phospholipid ratio of plasma membranes occurred in cholesterol-enriched macrophages. No changes were observed in phagolysosomes. Cholesterol-enriched macrophages showed a 35.8% inhibition of latex particles phagocytosis. When lipid droplets were substituted for latex the inhibition was 81.7%.Keywords
This publication has 24 references indexed in Scilit:
- Effect of cholesterol content on some physical and functional properties of mitochondria isolated from adult rat liver, fetal liver, cholesterol-enriched liver and hepatomas AH-130, 3924A and 5123Biochimica et Biophysica Acta (BBA) - Biomembranes, 1975
- Modulation of red cell K+ transport by membrane lipidsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1973
- Cholesterol in mycoplasma membranes. Composition, ultrastructure and biological properties of membranes from Mycoplasma mycoides var. capri cells adapted to grow with low cholesterol concentrationsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1973
- Cholesterol and phospholipid composition of mitochondria and microsomes isolated from morris hepatoma 51 23 and rat liverFEBS Letters, 1973
- Effect of cholesterol and water on the rigidity and order of phosphatidylcholine bilayersBiochimica et Biophysica Acta (BBA) - Biomembranes, 1972
- Erythrocyte membranes-effect of increased cholesterol content on permeabilityBiochimica et Biophysica Acta (BBA) - Biomembranes, 1971
- The Properties of Mitochondria Enriched in vitro with CholesterolEuropean Journal of Biochemistry, 1970
- Studies on phagocytosis: I. Uptake of radio-iodinated (131I) human serum albumin as a measure of the degree of phagocytosis in vitroExperimental Cell Research, 1969
- Membranes of animal cells. I. Methods of isolation of the surface membraneJournal of Cellular Physiology, 1966
- Biochemical Aspects of PhagocytosisNature, 1961