Semaphorin 4B interacts with the post‐synaptic density protein PSD‐95/SAP90 and is recruited to synapses through a C‐terminal PDZ‐binding motif
- 16 June 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (17) , 3821-3828
- https://doi.org/10.1016/j.febslet.2005.05.079
Abstract
The semaphorins are a large family of proteins that act as guidance signals for axons and dendrites. The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. Here, we show that a subclass of these semaphorins is characterized by a PDZ-binding motif at their carboxy-terminus. This sequence mediates the interaction with the post-synaptic density protein PSD-95/SAP90. Co-expression of Sema4B with PSD-95 in COS 7 cells results in the clustering of Sema4B. Sema4B co-localizes with PSD-95 at synaptic contacts between cultured hippocampal neurons. This synaptic localization depends on the presence of the PDZ-binding motifKeywords
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