CHARACTERIZATION OF NON-LYMPHOID CELLS IN RAT SPLEEN, WITH SPECIAL REFERENCE TO STRONGLY IA-POSITIVE BRANCHED CELLS IN T-CELL AREAS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 32  (3) , 167-178
Abstract
By use of a monoclonal antibody against Ia antigen in an immunoperoxidase method, strongly Ia-positive branched cells are found in the T-cell areas of the splenic white pulp of the rat. To further characterize these cells, enzyme histochemical characteristics, phagocytic capacity and irradiation sensitivity were studied. These strongly Ia-positive branched cells apparently represent interdigitating cells. The influence of whole-body irradiation on interdigitating cells is discussed. Comparison with data from the literature on the in vitro dendritic cell isolated from spleen cell suspensions reveals many similarities between the described interdigitating cell in vivo and the dendritic cell in vitro.

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