Oral phenytoin pharmacokinetics during omeprazole therapy.

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Abstract
1 In a double-blind crossover study 10 healthy males received either placebo or omeprazole (40 mg day-1) for 9 days, a single dose of phenytoin (300 mg) being taken on the seventh day. 2 Omeprazole significantly increased the area under the curve (0 to 72 h) of phenytoin (mean .+-. s.e. mean) from 121.6 .+-. 14.0 to 151.4 .+-. 13.6 .mu.g ml-1 h) (P < 0.010. 3 The peak concentration, and apparent elimination half-life of phenytoin also tended to be increased though not significantly. 4 The omeprazole-phenytoin interaction observed may be clinically important because of the low therapeutic index associated with phenytoin.