Enzymatic Activity of a Genetically Altered Tryptophan Synthetase in Neurospora crassa
- 12 June 1959
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 129 (3363) , 1614-1615
- https://doi.org/10.1126/science.129.3363.1614
Abstract
Partially purified preparations of certain tryptophan-requiring mutants of Neurospora crassa, which contain a protein (CRM) antigenically related to wild-type tryptophan synthetase, possess indole glycerol phosphate-synthesizing activity. This activity can be inhibited by anti-CRM sera. It is suggested that CRM in such mutants represents a damaged tryptophan synthetase lacking the capacity to react with l-serine.Keywords
This publication has 9 references indexed in Scilit:
- ON A MECHANISM OF SUPPRESSOR GENE REGULATION OF TRYPTOPHAN SYNTHETASE ACTIVITY IN NEUROSPORA CRASSAProceedings of the National Academy of Sciences, 1959
- The exclusion of free indole as an intermediate in the biosynthesis of tryptophan in Neurospora crassaBiochimica et Biophysica Acta, 1958
- THE ENZYMATIC ACTIVITY ASSOCIATED WITH THE PROTEIN IMMUNOLOGICALLY RELATED TO TRYPTOPHAN SYNTHETASEProceedings of the National Academy of Sciences, 1958
- Enzyme-Inhibitor Complex in a Tryptophan-Requiring Mutant of Neurospora crassaScience, 1957
- AN IMMUNOLOGICAL STUDY OF MUTANTS OF ESCHERICHIA COLI LACKING THE ENZYME TRYPTOPHAN SYNTHETASEJournal of Bacteriology, 1957
- PROPERTIES OF A PROTEIN ANTIGENICALLY RELATED TO TRYPTOPHAN SYNTHETASE INNEUROSPORA CRASSAJournal of Bacteriology, 1957
- CORRIGENDAGenetics, 1955
- ALLELIC STRAINS OF Neurospora LACKING TRYPTOPHAN SYNTHETASE: A PRELIMINARY IMMUNOCHEMICAL CHARACTERIZATIONProceedings of the National Academy of Sciences, 1955
- The Effects of Gene Change on Tryptophan Desmolase FormationProceedings of the National Academy of Sciences, 1952