Inhibition of Ornithine Decarboxylase Activity in Mouse Kidney by Administration of Diamines.
- 1 January 1979
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 33b (7) , 537-540
- https://doi.org/10.3891/acta.chem.scand.33b-0537
Abstract
On testosterone administration the hypertrophied kidneys of castrated mice exhibited a striking increase in the activity of ornithine decarboxylase (EC 4.1.1.17) and an accumulation of polyamines. The effect on ornithine decarboxylase activity could be inhibited by injections of putrescine or its homologues, 1,3-diaminopropane and 1,5-diaminopentane (cadaverine). Most effective was 1,3-diaminopropane which also restrained the accumulation of polyamines.Keywords
This publication has 3 references indexed in Scilit:
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- Inhibition of polyamine accumulation and deoxyribonucleic acid synthesis in regenerating rat liverBiochemical Journal, 1976
- Induction of a protein inhibitor to ornithine decarboxylase by the end products of its reaction.Proceedings of the National Academy of Sciences, 1976