ON THE PREVENTION OF CASTRATION EFFECTS IN MAMMALS BY TESTIS EXTRACT INJECTION

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Abstract
In studying the effects of castration on rats and guinea pigs the authors obtained several physiological and morphological (gross and cytological) indicators of castration. Each alone is capable of distinguishing the castrated animal from a normal one. By injecting fractions of a lipid extract of bull testes into rats and guinea pigs the authors not only prevented the development of the castration effects by injecting immediately after castration, but also were able to eliminate castration effects that had been present for some mos. The spermatozoon motility test (guinea pig), the electric ejaculation test (guinea pig), the prostate test (rat), and the seminal vesicle test (rat), all proved that the extracts injected were able to substitute for the internal secretion of the testicle. The authors found no castration change that failed to respond to the injections.