Anxiogenic activity of isatin, a putative biological factor, in rodents
- 1 May 1991
- journal article
- Published by SAGE Publications in Journal of Psychopharmacology
- Vol. 5 (3) , 202-206
- https://doi.org/10.1177/026988119100500304
Abstract
Isatin (2,3-dioxoindole) has been proposed as a new biological factor, responsible for at least part of the activity of tribulin, an endogenous monoamine oxidase and benzodiazepine receptor binding inhibitory factor, which may serve as an endocoid marker of stress and anxiety. The putative anxiogenic activity of isatin was investigated in rats and mice. The doses chosen for the study, namely 15 mg/kg i.p. in mice and 20 mg/kg i.p. in rats, were based on preliminary behavioural studies. Yohimbine, a well established anxiogenic agent, was used for comparison and used at doses of 2 and 2.5 mg/kg i.p. in mice and rats, respectively. The experimental paradigms chosen have been shown to stand the tests of validity and reliability. Isatin induced significant anxiogenic activity in the open-field and elevated plus-maze tests in mice, and the social interaction test in rats, which were comparable to those induced by yohimbine. In addition, both isatin and yohimbine attenuated the effects of the anxiolytic agent diazepam in the open-field test. The investigations indicate that isatin has significant anxiogenic effect and support the contention that it and/or its biotransformation products may be responsible for at least part of the activity of tribulin demonstrated previously in animal models and in clinical situations of stress and anxiety.Keywords
This publication has 24 references indexed in Scilit:
- Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulinJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1990
- Measures of anxiety and stress in the rat following chronic treatment with yohimbineJournal of Psychopharmacology, 1988
- Animal models of anxiety: the effect of compounds that modify 5-HT neurotransmissionTrends in Pharmacological Sciences, 1987
- Variations in the monoamine oxidase-inhibitory activity (?tribulin??) in pig's urineJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1987
- Distribution of endogenous benzodiazepine receptor ligand-monoamine oxidase inhibitory activity (tribulin) in tissuesLife Sciences, 1986
- Behavioral pharmacological profile of CGS 9895: A novel anxiomodulator with selective benzodiazepine agonist and antagonist propertiesDrug Development Research, 1985
- Animal models for the study of anti-anxiety agents: A reviewNeuroscience & Biobehavioral Reviews, 1985
- Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social BehaviourNeuropsychobiology, 1985
- Yohimbine induced anxiety and increased noradrenergic function in humans: Effects of diazepam and clonidineLife Sciences, 1983
- Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitorNature, 1981