Abstract
In the absence of proof that cytomegalovirus is the cause of colitis and retinitis in human immunodeficiency virus (HIV)-infected patients, it is proposed that HIV plays a direct role in the causation of these diseases. Clinical and epidemiologic evidence is cited to support this hypothesis. A direct role for HIV in the etiology of retinitis and colitis in HIV-infected patients could have important implications for antiviral chemotherapy in these diseases.

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