In vivo measurement of intracellular pH in human brain during different tensions of carbon dioxide in arterial blood. A 31P‐NMR study

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Abstract
The effect of changes in carbon dioxide tension in arterial blood upon intracellular pH in brain tissue was studied in seven healthy volunteers, aged 22–45 years. The pH changes were monitored by use of 31P nuclear magnetic resonance spectroscopy, performed on a whole‐body 1.5 Tesla Siemens imaging system. The measurements were carried out during hyperventilation and with the subject breathing atmospheric air containing 5 vol. % and 7 vol. % carbon dioxide. Intracellular pH increased significantly during 15 min of hyper‐ventilation and decreased significantly during 18 min respiration of air containing 7 vol. %, carbon dioxide. The intracellular buffer capacity was estimated. These results suggest that the ventilation response to carbon dioxide is correlated to changes in intracellular fluid pH.