Intra‐Erythrocytic Plasmodium falciparum Induces Up‐Regulation of Inter‐Cellular Adhesion Molecule‐1 on Human Endothelial Cells In Vitro

Publisher Website
Google Scholar
Abstract
The stimulation of human vascular endothelial cells with P. falciparum-infected erythrocytes resulted in the non-transient up-regulation of ICAM-1 expression on human endothelial cells. The induction was independent from TNF as assured in various controls including the application of a TNF-neutralizing antibody. The possibility that TNF is produced by endothelial cells was investigated in a purified culture of human endothelial cells by TNF-ELISA and TNF-bio-assay both with negative results. This result may be evidence of the existence of TNF-independent mechanisms in the pathogenesis of human cerebral malaria.