Progress and Deficiencies in the Registration of Clinical Trials

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Abstract
Clinical trials are essential to understanding the efficacy of medical interventions. The ethical underpinnings of this type of research involving human subjects, codified in the Belmont Report1 and the Declaration of Helsinki,2 require that the results be publicly available to inform medical practice as well as future research. In addition, basic principles of evidence-based practice require the analysis of all data on a given topic; the practice of publishing only some results, but not others,3,4 undermines our collective ability to make rational decisions about medical care.