CD8+CD28− T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity
- 1 August 2001
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 182 (1) , 201-206
- https://doi.org/10.1034/j.1600-065x.2001.1820116.x
Abstract
Summary: Human CD8+CD28− suppressor T cells (Ts) are a subset of T cells generated in the course of in vitro and in vivo immunizations. Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity. We have demonstrated for the first time that CD8+CD28− Ts represent a unique subset of regulatory cells that induces the differentiation of tolerogenic antigen‐presenting cells, initiating a suppressive loop which results in the induction and spreading of Th unresponsiveness.Keywords
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