Effects of Calcium, Strontium, and Barium Ions on Phosphorylation of Hippocampal Proteins In Vitro

1 January 1984

journal article
research article
Published by Wiley in Journal of Neurochemistry

Vol. 42 (1) , 54-58
https://doi.org/10.1111/j.1471-4159.1984.tb09697.x

Abstract

Calcium ion alone or in the presence of added calmodulin stimulated in vitro transfer of ³²P from [γ³²P]ATP into several proteins of mitochondrial and synaptosomal particulate fractions from rat brain. Strontium ion was capable of substituting for calcium ion in this stimulation, but barium ion lacked this capacity. These results bring into question the hypothesis that calciumdependent protein phosphorylation of synaptic proteins is intrinsic to neurotransmitter release during neurotransmission, but they do not rule out that possibility.

Keywords

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