METABOLISM OF 2-NITRO-1-PHENYLPROPANE TO PHENYLACETONE BY RABBIT LIVER-MICROSOMES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (1) , 75-82
Abstract
The enzymatic character of the reaction was demonstrated by the increase of product with microsomal protein and dependency on NADPH and O2. Phenobarbital induction markedly increased formation of phenylacetone. CO decreased the reaction indicating the involvement of a metalloenzyme. Experiments with H218O indicated that the carbonyl oxygen originated from H2O. The microsomal metabolism of 2-nitro-1-phenylpropane may involve an enzymatic step followed by chemical hydrolysis of an intermediate, possibly a secondary nitronic acid.

This publication has 0 references indexed in Scilit: