COMPARISON OF THE EFFECTS OF GLUCAGON AND ATROPINE SULFATE ON GASTRIC-EMPTYING

  • 1 January 1978
    • journal article
    • research article
    • Vol. 70  (6) , 581-586
Abstract
Symptomatic adult males [6] cooperated in a study of gastric emptying. Each subject was given a test meal of 500 ml of 3.5% glucose on a fasting stomach. Ten min prior to the meal each was given either 1 mg atropine sulfate, placebo, or 2 mg glucagon, double-blind and crossover. Each drug was given twice, i.v., in a random order. The meal was removed by a Salem sump tube 1/2 h after ingestion. When compared to placebo, the active drugs significantly (P < 0.05) slowed gastric emptying; atropine sulfate was more effective (P < 0.05) than glucagon. The active drugs significantly (P < 0.05) decreased total gastric acid secretion and total gastric Cl- as compared to placebo. Glucagon significantly (P < 0.05) increased the blood glucose concentration as compared to placebo. These results apparently indicate that both glucagon and atropine sulfate slow the gastric emptying of a liquid sugar meal from the stomach.

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