Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts.
- 1 June 1985
- journal article
- research article
- Published by Wiley in The EMBO Journal
- Vol. 4 (6) , 1491-1494
- https://doi.org/10.1002/j.1460-2075.1985.tb03807.x
Abstract
The tumor promoter phorbol-12-myristate-13-acetate (PMA) causes an increase in poly(ADP)-ribosylation in mouse and human fibroblasts via the intermediate formation of active O2. In contrast to poly(ADP)-ribosylation induced by the methylating agent N-methyl-N''-nitro-N-nitrosoguanidine, de novo RNA and protein synthesis are required and the accumulation of the polymer occurs in the absence of detectable DNA strand breakage. A mechanism for PMA-induced modulation of chromatin structure and gene expression is suggested.This publication has 25 references indexed in Scilit:
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