A Six‐Month Clinical Evaluation of Decalcified Freeze‐Dried Bone Allografts in Periodontal Osseous Defects

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Abstract
The osteogenic potential of decalcified freeze‐dried bone allografts in the treatment of human periodontal osseous defects was evaluated over a 6‐month period. Cortical bone, obtained under sterile conditions from a human donor within 24 hours after death, was decalcified, freeze‐dried and ground to a particle size of 250 to 500 μm. Twenty‐seven osseous defects with one‐, two‐ and wide three‐wall morphology were treated. Clinical measurements were made with a stent and a calibrated periodontal probe before surgery, at the time of surgery, and at re‐entry. The combined mean osseous regeneration for all defects was 2.4 mm. This represented a 65% mean bone‐fill of the original defect. The findings demonstrate that decalcified freeze‐dried bone allograft has potential as an osseous grafting material in periodontal therapy.