The direct n.m.r. observation of a slowly exchanging, enzyme-bound ligand via photo-CIDNP: a study of the human carbonic anhydrase B–sulphanilamide complex
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 12,p. 538-540
- https://doi.org/10.1039/c39800000538
Abstract
Sulphanilamide, a potent inhibitor of the enzyme carbonic anhydrase, showed a photo-CIDNP 1H n.m.r. spectrum; the resultant polarisation was maintained when the ligand was bound to the enzyme and a new resonance, arising from the slowly exchanging bound species, was observed.Keywords
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