Local synthesis of amyloid fibril precursor in AL amyloidosis of the urinary tract.
- 1 January 1998
- journal article
- case report
- Published by Taylor & Francis in Amyloid
- Vol. 5 (1) , 49-54
- https://doi.org/10.3109/13506129809007290
Abstract
An amyloid tumor localized to the urethra was resected and shown by immunohistochemistry to contain fibril deposits that stained with antisera specific for λVI immunoglobulin light chain. The amino acid sequence of the fibril protein was homologous to λVI Positive staining of subepithelial plasma cells with λVI specific monoclonal antibody was consistent with the hypothesis that the fibril precursor light chain protein is synthesized and processed locally to give this type of localized amyloidosis.Keywords
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