Elevated Alpha1-Antichymotrypsin Serum Levels in a Subset of Nondemented First-Degree Relatives of Alzheimer's Disease Patients
- 26 January 1995
- journal article
- research article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 6 (1) , 17-20
- https://doi.org/10.1159/000106917
Abstract
A portion of Alzheimer''s disease (AD) patients have elevated serum levels of the acute phase reactant α1-antichymotrypsin (A1ACT) compared to age-matched controls. We measured serum levels of A1ACT in AD patients, age-matched controls, Down''s Syndrome patients, and nondemented first-degree relatives of AD patients. Significantly elevated levels of A1ACT were found in both AD patients and first-degree-relatives. In AD patients, serum A1ACT concentrations decreased with increasing severity of cognitive impairment. These results may suggest that inflammatory phenomena may be an early component of AD pathophysiology.Keywords
This publication has 0 references indexed in Scilit: