A transcript family from a long-range repeat cluster of the house mouse

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Abstract
A family of closely related genes is a component of the polymorphic long-range repeat cluster D1Lub1 of the house mouse. Members of the gene family have diverged from one another by rearrangements and point mutations. D1Lub1 clusters have low (≈50) or high (≥500) copy numbers. In mice with high-copy clusters five or six poly(A)+ RNAs are found, while in mice with low-copy clusters only a single member of the RNA family is detected. The RNA family is synthesized in a tissue-independent manner. Each member of the RNA family is defined by a set of DNA probes. Cross hybridization with the probes reveals common 5′ regions and variable remaining parts. The RNA variants are probably transcribed from different gene copies.Key words: long-range repeat cluster, long-range repeat derived gene family, mRNA family.