Misoprostol for the Treatment of Peptic Ulcer and Antiinflammatory-Drug–Induced Gastroduodenal Ulceration
- 26 November 1992
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 327 (22) , 1575-1580
- https://doi.org/10.1056/nejm199211263272207
Abstract
MISOPROSTOL was the first analogue of prostaglandin E1 to be commercially available. It was developed after prostaglandins of the E series had been found to inhibit the secretion of acid and prevent gastric injury caused by various substances, with the hope that it would be useful for the prevention and treatment of gastrointestinal ulceration. The aim of this article is to review the use of the drug in clinical practice, with critical appraisal of its role in the prevention and management of upper gastrointestinal ulcers associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs). In the United Kingdom, misoprostol . . .Keywords
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