An analysis of the inhibition of pyruvate oxidation by arsenicals in relation to the enzyme theory of vesication

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Abstract
The pyruvate oxidase system was the most sensitive of the oxi-dases to trivalent arsenical poisoning, and the pyruvate dehydrogenase the most sensitive of the dehydrogenases studied but less sensitive than the whole oxidase of the brain. Lewisite, in general, proved more toxic than arsenite. None of the coenzymes at present known to be associated with pyru- vate oxidase system was sensitive. In vivo, the blood pyruvate level was significantly raised in animals poisoned with arsenite or lewisite. It appeared that a basis has been formed for the enzyme theory of vesication and that the first point of attack of arsenicals was on pyruvate oxidation.

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