Lipase-Catalyzed Esterification
- 30 November 2000
- journal article
- Published by Taylor & Francis in Catalysis Reviews
- Vol. 42 (4) , 439-480
- https://doi.org/10.1081/cr-100101953
Abstract
Lipases are versatile catalysts. In addition to their natural reaction of fat hydrolysis, lipases catalyze a plethora of other reactions such as esterification, amidation, and transesterification of esters as well as organic carbonates. Moreover, lipases accept a wide variety of substrates while maintaining their regioselectivity and stereoselectivity. Lipases are highly stable even under adverse conditions such as organic solvents, high temperatures, and so forth. Applications of lipases include production of food additives, chiral intermediates, and pharmaceutical products. Among these, synthesis of various chiral intermediates in pharmaceutical industry and cocoa butter substitutes is being commercially exploited currently. Lipase-catalyzed esterification and transesterification in anhydrous media (e.g., organic solvents and supercritical fluids) has been an area of major research activity in the past decade or so. Absence of water eliminates the competing hydrolysis reaction. Moreover, substrate speci...Keywords
This publication has 214 references indexed in Scilit:
- Lipase-catalyzed dynamic resolution of naproxen 2,2,2-trifluoroethyl thioester by hydrolysis in isooctaneBiotechnology & Bioengineering, 1999
- Large-scale preparation of (Z)-3-hexen-1-yl acetate usingCandida antarctica-immobilized lipase in hexaneBiotechnology & Bioengineering, 1998
- Influence of the nature of modifier in the enzymatic activity of chemical modified semipurified lipase fromCandida rugosaBiotechnology & Bioengineering, 1997
- Crystal Structure of a Bacterial Lipase fromChromobacterium viscosumATCC 6918 Refined at 1.6 Å ResolutionJournal of Molecular Biology, 1996
- 1·8 Å Refined Structure of the Lipase from Geotrichum candidumJournal of Molecular Biology, 1993
- Short chain flavour esters synthesis by microbial lipasesBiotechnology Letters, 1990
- Enzyme denaturation in supercritical CO2: Stabilizing effect of S-S bonds during the depressurization stepBiotechnology Letters, 1988
- Magnetic lipase active in organic solventsBiochemical and Biophysical Research Communications, 1986
- Enzymatic catalysis in a supercritical fluidBiotechnology Letters, 1985
- Action de la lipase pancréatique sur les esters en émulsionBiochimica et Biophysica Acta, 1958