Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (9) , 940-945
- https://doi.org/10.7164/antibiotics.33.940
Abstract
A novel antitumor antibiotic complex was obtained from the culture broth of Actinomycete strain DO-11 (KY11091) isolated from a soil sample collected in Sendai, Miyagi, Japan. On the taxonomic studies the producing organism is described as Micromonospora chalcea KY11091. For the production of the antibiotics, soluble starch served as a good C source and yeast extract was the best N source tested. The antibiotic complex designated as tetrocarcins is active against gram-positive bacteria, but is not active against gram-negative bacteria. Tetrocarcin A showed bacteriocidal activity against Bacillus subtilis.This publication has 1 reference indexed in Scilit:
- Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.The Journal of Antibiotics, 1980