Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5′ end of the lactase gene on chromosome 2q21
- 2 December 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 398 (2-3) , 135-140
- https://doi.org/10.1016/s0014-5793(96)01189-1
Abstract
Four exons of a human homologue of a yeast cell division cycle gene (MCM6/mis5, which is thought to encode a DNA replication licensing factor) have been identified 3.3 kb upstream from the start of transcription of the intestinal lactase gene on human chromosome 2q21, initially by similarity to a rat ‘intestinal crypt-cell replication factor’. RT-PCR analysis shows, that unlike lactase, MCM6 is not restricted in its tissue distribution and does not show person-to-person variation in the level of expression in adult intestineKeywords
This publication has 23 references indexed in Scilit:
- The role of MCM proteins in the cell cycle control of genome duplicationBioEssays, 1996
- Two additional polymorphisms within the hypervariable MUC1 gene: association of alleles either side of the VNTR regionAnnals of Human Genetics, 1996
- Conservation of Position and Sequence of a Novel, Widely Expressed Gene Containing the Major Human α-Globin Regulatory ElementGenomics, 1995
- Rat intestinal crypt-cell replication factor with homology to early S-phase proteins required for cell divisionGene, 1995
- Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replicationCytogenetic and Genome Research, 1995
- The MCM2-3-5 proteins: are they replication licensing factors?Trends in Cell Biology, 1994
- Population Sequence Analysis of a Simian Immunodeficiency Virus (32H Reisolate of SIVmac251): A Virus Stock Used for International Vaccine StudiesAIDS Research and Human Retroviruses, 1992
- A role for the nuclear envelope in controlling DNA replication within the cell cycleNature, 1988