INTERLEUKIN 2, INTERFERON, AND LYMPHOTOXIN IN RENAL TRANSPLANT RECIPIENTS1 Pressented at the 6th Annual Meeting of the American Society of Transplant Physicians, May 1987, Chicago, IL

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Abstract
The immunocuppressive action of cyclosporine in transplantation (Tx) is thought to be due to its potent inhibition of lymphokine production by T cell. Several studies have shown a decrease in interleukin 2 (IL–2) adn interferon-Gamma (IFN-G) production of renal Tx recipients on CsA treatment and have suggested that increased in lymphokine production can be correlatede with rejection epidosodes.In this study we measured IL-2, IFN-G, and lymphotoxin (LT) production by mitogen-stmulated peripheral blood lymphocytes in eight renal Tx recipients before and at various times after Tx. IL-2 production was significantly (PPP<0.05) after treatment. We conclude from these studies that the usefulness of lymphokine determinations for the diagnosis of allograft rejection remians unproved.