Frequent Loss of the Cyclin‐dependent Kinase‐4 Inhibitor Gene in Human Gliomas
Open Access
- 1 April 1995
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 86 (4) , 342-346
- https://doi.org/10.1111/j.1349-7006.1995.tb03062.x
Abstract
Studies have shown that homozygous deletion of the cyclin‐dependent kinase‐4 inhibitor (CDK41) gene, which is mapped to chromosome 9p21, is frequently observed in various types of human cancers. Here we report that the CDK4I gene was deleted in gliomas. Eight cell lines derived from glioblastomas and samples from 14 patients with various grades of gliomas were examined by Southern blot analysis. We found that the CDK4I gene was deleted in 7 of 8 (87.5%) cell lines and 7 of 9 (78%) samples from high‐grade glioma patients, whereas it was deleted in 1 of 5 (20%) low‐grade glioma samples. These results suggested that inactivation of the CDK4I gene may play an important role in the progression of human glioma.Keywords
This publication has 29 references indexed in Scilit:
- pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrestNature, 1994
- Rates of p16 ( MTS1 ) Mutations in Primary Tumors with 9p LossScience, 1994
- P16 gene in uncultured tumoursNature, 1994
- A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor TypesScience, 1994
- Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancersNature, 1994
- A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4Nature, 1993
- Molecular genetics of primary intracranial tumorsCurrent Opinion in Oncology, 1990
- Deletions of Interferon Genes in Acute Lymphoblastic LeukemiaNew England Journal of Medicine, 1990
- Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.Proceedings of the National Academy of Sciences, 1988
- Rapid DNA PreparationPublished by Elsevier ,1986