PROSPECTIVE-STUDY OF THE PULMONARY TOXICITY OF CONTINUOUSLY INFUSED BLEOMYCIN
- 1 January 1981
- journal article
- research article
- Vol. 65 (5-6) , 419-425
Abstract
Bleomycin is an effective antitumor drug but must be used cautiously because of its pulmonary toxicity. A prospective study was performed of the effects on pulmonary function when bleomycin was given as a continuous i.v. infusion over a 7-day period. Bleomycin was administered at a dose of 15 units/m2 as an i.v. push followed by 15 units/m2 per day as a continuous i.v. drip. Thirteen previously untreated patients completed the study after receiving a mean total dose of 228 units. Pulmonary function tests were performed before bleomycin treatment and periodically during the subsequent 6 mo. There was a small mean increase in both vital and diffusing capacities after 6 mo., which was not statistically significant. No patient had a serious loss in pulmonary function. The risk of bleomycin toxicity is low when the drug is given at this dose by continuous infusion. The risk may be less than the risk of toxicity from bolus injection in this dose range.This publication has 10 references indexed in Scilit:
- ROLE OF SINGLE-BREATH CARBON MONOXIDE-DIFFUSING CAPACITY IN MONITORING THE PULMONARY EFFECTS OF BLEOMYCIN IN GERM-CELL TUMOR PATIENTS1979
- IMPROVED THERAPEUTIC INDEX OF BLEOMYCIN WHEN ADMINISTERED BY CONTINUOUS INFUSION IN MICE1978
- MITOMYCIN-C, VINCRISTINE, AND BLEOMYCIN THERAPY FOR ADVANCED CERVICAL-CANCER1978
- Bleomycin Hypersensitivity PneumonitisAnnals of Internal Medicine, 1978
- Clinical pharmacologic and therapeutic studies of bleomycin given by continuous infusionCancer, 1977
- Cis-diamminedichloroplatinum (II)Annals of Internal Medicine, 1977
- Cytotoxic drug-induced lung diseaseThe American Journal of Medicine, 1977
- Intravenous bleomycin infusion as a potential syncronizing agent in human disseminated malignancies.A preliminary reportCancer, 1976
- Cyclophosphamide therapy and interstitial pulmonary fibrosisCancer, 1976
- Bleomycin, an Antitumor AntibioticAnnals of Internal Medicine, 1972