Some comments on potency measures in mutagenicity research.
Open Access
- 1 January 1994
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 102 (suppl 1) , 91-94
- https://doi.org/10.1289/ehp.94102s191
Abstract
In this article, the measurement of the potency of a chemical or mixture from its dose response in a particular assay is addressed. Attention is focused on data from the Ames Salmonella assay. Three measures of potency are explored and shown to be highly correlated. The presentation then discusses specific areas of research that might benefit from a study of potency.Keywords
This publication has 10 references indexed in Scilit:
- Predicting Rodent Carcinogenicity from Four in vitro Genetic Toxicity Assays: An Evaluation of 114 Chemicals Studied by the National Toxicology ProgramJournal of the American Statistical Association, 1990
- Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicalsEnvironmental and Molecular Mutagenesis, 1990
- Exploring relationships between mutagenic and carcinogenic potenciesMutation Research/Reviews in Genetic Toxicology, 1988
- Statistical Aspects of Using Biologic MarkersStatistical Science, 1988
- Handling Antineoplastic Agents: Urine Mutagenicity in NursesImage: the Journal of Nursing Scholarship, 1987
- Prediction of Chemical Carcinogenicity in Rodents from in Vitro Genetic Toxicity AssaysScience, 1987
- Prediction of environmental carcinogens: A strategy for the mid‐1980sEnvironmental Mutagenesis, 1984
- An empirical approach to the statistical analysis of mutagenesis data from the Salmonella testMutation Research/Environmental Mutagenesis and Related Subjects, 1982
- Statistical analysis of the Ames Salmonella/microsome test.Proceedings of the National Academy of Sciences, 1981