INFLUENCE OF DIFFERENT ADJUVANTS ON THE PRODUCTION OF IGD AND IGE ANTIBODIES

  • 1 January 1979
    • journal article
    • research article
    • Vol. C130  (1) , 49-58
Abstract
The relationship between the synthesis of Ig[immunoglobulin]D and IgE antibodies upon antigen administration was investigated. Different adjuvants were used to find the optimal way of inducing the synthesis of IgD and IgE antibodies in rats. Ovalbumin was used as antigen. Fair amounts of IgE antibodies were produced using Al(OH)3 or Bordetella pertussis and Al(OH)3 as adjuvant. Only small quantities of IgE antibodies were formed when Freund''s complete adjuvant (FCA) or no adjuvant were used. IgD antibodies were formed upon the immunization with ovalbumin and FCA or B. pertussis in combination with Al(OH)3. Using Al(OH)3 alone as adjuvant or antigen alone resulted in only very minute quantities of specific IgD. Total serum IgE levels were raised in the rats immunized with Al(OH)3 or B. pertussis and Al(OH)3. Total serum IgD was increased after immunization with ovalbumin and B. pertussis in combination with Al(OH)3.

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