Role of solute drag in intestinal transport.

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Abstract
The role of solvent drag and solute drag in the transmembrane movement of nonelectrolytes in a perfused rat intestine preparation was investigated. Conditions were chosen to simulate the effects of luminal hypersomolarity on the permeability of tracer solutes. Net water flux, transepithelial potentials and lumen-to-blood and blood-to-lumen tracer solute movements were noted during control electrolyte perfusion and after making the perfusate hyperosmotic. Both solvent drag and solute drag can play significant roles in the transepithelial movement of solute and solute permeabilities in the rat ileum preparation. The potential roles of solvent drag and solute drag should be accounted for or considered during the characterization of the mechanisms of biological membrane function.