Standardization of an Experimental Murine Model of Invasive Pulmonary Aspergillosis
- 1 October 2006
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (10) , 3501-3503
- https://doi.org/10.1128/aac.00787-06
Abstract
Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.Keywords
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